GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs76419734 | 1 | rs11734571 | chr4:106703557 | INTS12 | chr4:106603787-106629881:- | -0.3 | -3.72 | 0.000212 | Post bronchodilator FEV1 |
| BRCA | cis | rs7694379 | 1 | rs11735092 | chr4:88226231 | HSD17B11 | chr4:88257691-88312455:- | 0.14 | 5.14 | 3.3E-7 | Platelet count |
| BRCA | cis | rs76419734 | 1 | rs11735213 | chr4:106527508 | INTS12 | chr4:106603787-106629881:- | -0.27 | -3.55 | 0.000397 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11735527 | chr4:106679692 | INTS12 | chr4:106603787-106629881:- | -0.31 | -3.82 | 0.00014 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11736859 | chr4:106708785 | INTS12 | chr4:106603787-106629881:- | -0.3 | -3.72 | 0.000212 | Post bronchodilator FEV1 |
| BRCA | cis | rs2036402 | 1 | rs11737950 | chr5:156436211 | TIMD4 | chr5:156346293-156390266:- | -0.16 | -4.16 | 3.44E-5 | Hypertriglyceridemia |
| BRCA | cis | rs1853207 | 1 | rs117381226 | chr10:96553520 | C10orf129 | chr10:96953957-96988685:+ | 0.25 | 4.5 | 7.66E-6 | Blood metabolite levels |
| BRCA | cis | rs1116547 | 1 | rs11738215 | chr5:112719477 | YTHDC2 | chr5:112849410-112930979:+ | -0.12 | -3.65 | 0.000279 | Cerebral amyloid angiopathy |
| BRCA | cis | rs10461617 | 1 | rs11739344 | chr5:56111087 | C5orf35 | chr5:56205103-56213010:+ | 0.77 | 19.51 | 9.38E-73 | Type 2 diabetes |
| BRCA | cis | rs1853207 | 1 | rs117395468 | chr10:96529544 | C10orf129 | chr10:96953957-96988685:+ | 0.21 | 3.91 | 9.94E-5 | Blood metabolite levels |
| BRCA | cis | rs17504106 | 1 | rs11739699 | chr5:160450185 | SLU7 | chr5:159828649-159846168:- | 0.14 | 4.02 | 6.22E-5 | Post-traumatic stress disorder |
| BRCA | cis | rs6452524 | 1 | rs11740478 | chr5:82446386 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.53 | 0.000433 | Hypertension |
| BRCA | cis | rs2036402 | 1 | rs11740496 | chr5:156435402 | TIMD4 | chr5:156346293-156390266:- | 0.15 | 3.91 | 0.0001 | Hypertriglyceridemia |
| BRCA | cis | rs2036402 | 1 | rs11740499 | chr5:156431741 | TIMD4 | chr5:156346293-156390266:- | -0.15 | -4.02 | 6.2E-5 | Hypertriglyceridemia |
| BRCA | cis | rs7714584 | 1 | rs11741861 | chr5:150277909 | LOC134466 | chr5:150310000-150326146:- | -0.43 | -8.97 | 1.33E-18 | Crohn's disease |